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. 2015 Jan 30;29(5):1817–1829. doi: 10.1096/fj.14-267849

Figure 3.

Figure 3.

Effects of MRT-92 on GCPs and Shh medulloblastoma cell proliferation. A) Antagonist potency of MRT-92 on SAG (0.01 µM)-induced proliferation of rat cerebellar GCPs. Inhibition curve was generated using increasing concentrations of MRT-92 and the values are expressed as a percentage of the maximal response induced by SAG. B) Antagonist activity of MRT-92 on Ptc+/− medulloblastoma cells’ metabolic activity. MRT-92 (0.3 µM), GDC-0449 (3 µM), 17-DMAG (0.5 µM), or XAV939 (3 µM) was added into the medium of Ptc+/− medulloblastoma culture cells, and metabolic activity was measured 48 hours later. Data are means ± sem (n = 3) of a representative experiment over 4 independent experiments (A) or of 4 independent experiments (B). ***P ≤ 0.001.