TABLE 1.
Group | n | Inhibitor | Dose, mg/kg | Injection volume i.v., μl | Including DMSO, μl | Administrationa | Immunization |
---|---|---|---|---|---|---|---|
1 | 10 | PS-341 | 0.5 | 250 | 10 | + | + |
2 | 10 | β1i-PEk | 0.5 | 250 | 10 | + | + |
3 | 10 | — | — | 250 | 10 | + | + |
4 | 5 | — | — | 250 | 10 | + | – |
5 | 5 | — | — | — | 0 | – | + |
6 | 5 | — | — | — | 0 | – | – |
Twice weekly starting from day 0 after immunization, 7 times total.