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Combinations of suboptimal doses of compounds that act on different G protein signaling pathways show additive effects on superoxide inhibition in 661W cells. Simultaneous inhibition of the Gq and Gs pathways with Dox and RO (RO-04-6790) or inhibition of the Gi and activation of the Gq pathways with Dox and Gub resulted in greater suppression of superoxide generation than single therapies. Studies were performed as described in the legend for Fig. 2. n = 4–5 for all groups.
