TABLE 3.
Effect of Dox or Apo on diabetes-induced defects in the visual function of mice after 2 or 8 months duration of diabetes
| Category | Duration (mo) | n | Spatial frequency threshold (c/d) | Contrast sensitivity |
|---|---|---|---|---|
| Nondiabetic control | 2 | 4 | 0.399 ± 0.009 | 26.9 ± 0.9a |
| Diabetic control | 2 | 4 | 0.379 ± 0.003b | 21.8 ± 1.3a,b |
| Diabetic + Dox | 2 | 4 | 0.375 ± 0.008b | 23.1 ± 0.8a,b |
| Diabetic + Apo | 2 | 4 | 0.374 ± 0.006b | 23.3 ± 1.0a,b |
| Nondiabetic | 8 | 5 | 0.396 ± 0.006 | Fig. 9D |
| Diabetic control | 8 | 5 | 0.358 ± 0.006b | Fig. 9D |
| Diabetic + Dox | 8 | 5 | 0.349 ± 0.006b | Fig. 9D |
| Diabetic + Apo | 8 | 5 | 0.351 ± 0.004b | Fig. 9D |
Assays were performed in vivo as described in the Materials and Methods section. All animals were 2 months of age at initiation of diabetes.
a
At 0.064 c/d.
b
P < 0.01 compared with nondiabetic control.