Figure 6.

CLR03 facilitates Aβ42 oligomer formation: (a) ATD of the z/n = −3 peak for Aβ42 alone, (b and c) ATDs of z/n = −3 Aβ42 without and with CLR03 bound for a 1:10 mixture of Aβ42 and CLR03, (d) ATD of the z/n = −4 peak for Aβ42 alone, (e and f) z/n = −4 Aβ42 without and with CLR03 bound for a 1:10 mixture of Aβ42 and CLR03. Each ATD is fit with multiple features using the procedure described in the Experimental Methods section. M₁ and M₂ represent two conformations of the Aβ42 monomer. The arrows indicate the formation of oligomers (n ≥ 2) in the mixture of Aβ42 and CLR03.