Table 2. Selected examples of unexpected but reliable Meta-BASIC predictions.
| DUF | PfamA | Name | Score | PDB | Name | Score |
|---|---|---|---|---|---|---|
| DUF271 | PF01501 | Glycosyl transferase family 8 | 23.55 | 1ll0A | Glycogenin-1 | 23.70 |
| DUF431 | PF04243 | tRNA m(1)G methyltransferase | 17.06 | 1ipaA | RNA 2′-O-Ribose Methyltransferase | 10.81 |
| DUF393 | PF00462 | Glutaredoxin | 13.29 | 1fovA | Glutaredoxin 3 | 14.16 |
| DUF920 | PF00797 | N-acetyltransferase | 13.02 | 1e2tA | N-Hydroxyarylamine O-Acetyltransferase | 15.57 |
| DUF833 | PF03577 | Peptidase family U34 | 12.73 | 3pvaA | Penicillin V Acylase | 9.24 |
Five out of twenty-six significant similarities between PfamA families with unknown function (DUF) and other PfamA families detected by Meta-BASIC but not with Meta-Blast E-value below 10 are displayed in left part of the table. The structural assignment for the five families based on detected similarities to proteins of known structure is reported in the right part. In all cases the name of the related family or protein and the Meta-BASIC score is shown. Only first, strongest PfamA and PDB hits are listed. Our literature search indicated that these similarities for the selected DUF families have not been reported before.