Figure 2.

Forest plot of risk-stratified hazard rates for disease-specific mortality associated with contralateral prophylactic mastectomy (CPM). Hazard ratios (HRs; solid circles) and 95% confidence intervals (shown by the whiskers on both sides of the solid circles) were derived by multivariable Cox regression analysis, adjusted for number of positive lymph nodes (0 vs 1–3 vs ≥4), tumor grade (1 vs 2 vs 3 vs 4), ethnicity and/or race (non-Hispanic white vs Hispanic white vs Black vs Asian or Pacific Islander vs other), tumor histology (nonlobular vs lobular), and first tumor indicator (yes vs no). All P values were calculated using Cox regression with the Wald test for significance. All P values were two-sided. ER = estrogen receptor.