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. 2010 Mar 17;102(6):401–409. doi: 10.1093/jnci/djq018

Figure 3.

Figure 3

Adjusted breast cancer–specific survival function associated with contralateral prophylactic mastectomy (CPM) for young women with early-stage breast cancer. A) Women with estrogen receptor (ER)–positive tumors (hazard ratio [HR] for death = 0.88, 95% confidence interval [CI] = 0.66 to 1.17; P = .38). B) Women with ER-negative tumors (HR for death = 0.68, 95% CI = 0.53 to 0.88; P .004). Hazard ratios and 95% confidence intervals were derived by multivariable Cox regression analysis, adjusted for number of positive lymph nodes (0 vs 1–3 vs ≥4), tumor grade (1 vs 2 vs 3 vs 4), ethnicity and/or race (non-Hispanic white vs Hispanic white vs Black vs Asian or Pacific Islander vs other), tumor histology (nonlobular vs lobular), and first tumor indicator (yes vs no). Percentages of women alive within the CPM and non-CPM groups at 3, 5, and 7 years are indicated on the curves. All P values are two-sided and were calculated using Cox regression with the Wald test for statistical significance.