. Author manuscript; available in PMC: 2015 Oct 28.

Published in final edited form as: Nat Commun. 2015 Apr 28;6:6342. doi: 10.1038/ncomms7342

Table 1. Study design, time schedule and sampling.

ED 1 and ED 2 are the initial and final endoscopy days, HE is the home environment and DI is dietary intervention periods. The Xs corresponding to dietary evaluation indicate the frequency of dietary recordings; three days during the home environment when consuming their usual diets, and daily during the dietary intervention.

Day	0	7	14	15	22	29
	HOME ENVIRONMENT (HE) STUDY			DIETARY INTERVENTION (DI)
	at home			in-house
Period	ED 1	HE 1	HE 2	DI 1	DI 2	ED 2
Faecal Samples	X	X	X	X	X	X
Colonic evacuates	X					X
Breath H₂, CH₄	X	X	X	X	X	X
Bloods	X					X
Mucosal biopsies	X					X
Dietary observations		XXX		X X X X X X X X X X X X X X