Table 1.

List of Biopsies Included in This Study With Patient Clinicopathologic Parameters and Immunohistochemical Staining Scores for Tyrosine-Phosphorylated (activated) STAT3, STAT3, and MMP-1

No.	Histology	TNM	Grade	Sex	pYSTAT3	STAT3	MMP-1
1	SCC	T2, N0, M0	G2	m	−	−	+++
2	NSCLC	T1, N3, M0	G2	w	++	++	++
3	AC	T1, N0, M0	G2	w	+++	+++	+++
4	SCC	T2, N1, M0	G2	m	++	++	+++
5	LCC	T1, N0, M0	G2	m	+	+	+
6	NSCLC	T2, N2, M0	G2	m	+	++	++
7*	NSCLC	n.d.	n. d.	n. d.	+++	+++	+
8	AC	T4, N0, M0	G2	m	−	+	++
9*	NSCLC	n.d.	n. d.	n. d.	++	++	+
10	SCC	T2, N1, M0	G3	m	++	+++	+
11	AC	T1, N0, M0	G2	m	−	−	++
12*	NSCLC	n.d.	n. d.	n. d.	+	+	++
13	SCC	T1, N1, M0	G2	m	++	+++	++
14	SCC	T4, N3, M0	G3	m	+++	+++	++
15	AC	T1, N1, M0	G2	w	++	++	+++
16	SCC	T2, N1, M0	G3	w	++	+++	+
17	SCC	T2, N2, M0	G3	m	++	+++	++
18	SCC	T2, N1, M0	G3	m	+++	+++	+++
19	SCC	T2, N0, M0	G2	m	++	++	++
20	NSCLC	T1, N1, M0	G1	m	+	+	++
21	AC	T1, N1, M0	G2	m	+	+++	++
22	AC	T2, N0, M0	G2	w	−	−	++
23	AC	T2, N0, M0	G3	m	−	+	+++
24	SCC	T2, N0, M0	G2	m	+++	+++	+++

A tripartite, graded immunoreactive score considering both staining intensities and percentage of signal-positive cells was employed. n.d., not defined. Asterisks indicate samples originating from open biopsies, i.e., from patients who were not treated surgically and were not included in follow-up surveys.