Figure 8.

Evidence of chest space volume increase due to tumor growth. (A) The volume of the automatically generated ROI (on the y-axis) was larger at higher tumor burden (SCP on the x-axis). (B) The change in the ROI volume from pre-treatment to post-treatment in individual mice was also correlated with the change in tumor burden. However, the air space volume within the ROI did not depend on the tumor burden (C). This shows that the chest space volume in the mice increased with increasing tumor burden. The mice likely compensate for the space taken up by the tumors by increasing the chest space to maintain adequate functional lung capacity and ventilation.