Skip to main content
. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2014 Nov 3;50(1):31–53. doi: 10.3109/10409238.2014.978975

Figure 1.

Figure 1

General schematic of RCNA and RINA. (Top) Replication-coupled nucleosome assembly (RCNA). Nucleosomes must be disassembled to make way for DNA replication machinery. Nucleosomes are then (re)assembled in close concert with DNA replication on the leading and lagging strands. (Bottom) Replication-independent nucleosome assembly (RINA). Many of the same core principles of nucleosome disassembly, DNA access and nucleosome assembly are likely applicable to replication-independent processes like gene transcription.