Table 3.

Generalized comparisons of Rtt109 and p300.

	Rtt109	p300	Key references
Catalyzes H3K56ac	Y	Y	(Das et al., 2009; Han et al., 2007)
Found in mammalian cells	N	Y	–
Found in fungi	Y	N	–
Proposed enzymatic mechanism	Sequential (random)	Theorell-Chance	(Albaugh et al., 2010; Liu et al., 2008)
Substrate binding order	Non-obligate	Obligate	(Albaugh et al., 2010; Liu et al., 2008)
Multiple histone residue substrates	Y	Y	(McManus & Hendzel, 2003)
Known non-histone substrates	N	Y	(Barlev et al., 2001; Sakaguchi et al., 1998)
Inhibition by Lys-CoA	N	Y	(Cebrat et al., 2003; Sagar et al., 2004; Tang et al., 2008)
Acetylates nucleosomes	N	Y	(Han et al., 2007b; Ogryzko et al., 1996)
Contains bromodomain	N	Y	(Manning et al., 2001)
Autoacetylation	Y	Y	(Albaugh et al., 2010, 2011; Arif et al., 2007; Karanam et al., 2006)
Intra/intermolecular autoacetylation	Intra-	Inter-	(Albaugh et al., 2010, 2011; Karanam et al., 2006)
Other post-translational modifications	N	Y	(Girdwood et al., 2003)
Size (aa)	436	2414	(Chan & Thangue, 2001; Johnston et al., 1997)