Table 2.

Leukocyte Count and Plasma C-reactive Protein Level at Enrollment and After Enrollment in the CANONIC Study from All Patients and the Specific Group of Patients Without Bacterial Infection.^e

	No ACLF	ACLF (all grades)	P value
At enrollment (all patients)a
Leukocyte count (×109/L)	6.8 ± 4.1	10.1 ± 0.4	<0.01
C-reactive protein (mg/L)	25.4 ± 31.9	39.4 ± 42.7	<0.01
At enrollment (patients without bacterial infection)b
Leukocyte count (×109/L)	6.6 ± 3.8	9.4 ± 5.3	<0.01
C-reactive protein (mg/L)	20.9 ± 24.5	33.4 ± 38.5	<0.01
After enrollment (all patients)c
Leukocyte count (×109/L)	5.9 ± 4.0	9.3 ± 5.7	<0.01
C-reactive protein (mg/L)	18.1 ± 17.7	36.2 ± 35.9	<0.01
After enrollment (patients without bacterial infection)d
Leukocyte count (×109/L)	6.0 ± 3.9	9.0 ± 5.4	<0.01
C-reactive protein (mg/L)	16.2 ± 14.6	34.4 ± 37.7	<0.01

^aLeukocyte count and plasma C-reactive protein levels were measured in 1037 and 762 patients without ACLF and in 302 and 249 patients with ACLF, respectively.

^bLeukocyte count and plasma C-reactive protein level were measured in 759 and 550 patients without ACLF and in 176 and 142 patients with ACLF, respectively.

^cLeukocyte count and plasma C-reactive protein level were measured in 216 and 183 patients without ACLF and in 112 and 85 patients with ACLF, respectively.

^dLeukocyte count and plasma C-reactive protein level were measured in 158 and 130 patients without ACLF and in 82 and 64 patients with ACLF, respectively.

^eAdapted from Ref. 7. Data are means ± SD.