Figure 2.

Ablation of α-cell TASK-1 channels reduces K2P current amplitude. A, Representative mouse α-cell K2P currents from control α-cells (black trace) and α-cells with TASK-1 ablation (gray trace, currents recorded in 14mM glucose, 100μM tolbutamide, and 10mM TEA; currents recorded in response to a voltage ramp from −120 to 60 mV over a 1-s interval). B, Average α-cell K2P current amplitude at +60 mV with (black bar) or without TASK-1 channels (gray bar; currents are normalized to cell capacitance; ±SEM; *, P < .05).