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. 2015 Mar 26;29(5):765–776. doi: 10.1210/me.2014-1355

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Figure 5. — TBC promotes cholesterol uptake by human intestinal cells. A, Western blot analysis of PXR levels in human intestinal LS180 cells transfected with control siRNA or siRNA against PXR (siPXR). B, Control or siPXR LS180 cells were treated with 10 μM TBC for 3 hours, and NPC1L1 expression was analyzed by qPCR (n = 3; ***, P < .001). C, Control or siPXR LS180 cells were treated with 10 μM TBC for 2 hours followed by incubation with [³H]cholesterol and TBC for an additional 1 hour. The cellular cholesterol uptake was then measured (n = 3; *, P < .05; and **, P < .01).