Table 1. Comparison of the computed lowest normal mode frequencies of Crambin (PDB id: 1CNR) with those derived from a normal mode study and quasi-harmonic analysis by Teeter and Case (49).

Our method	Normal mode analysis by Teeter and Case (DISCOVER potential functions)	Quasi-harmonic analysis by Teeter and Case (100 ps simulation time)
4.3	4.7	2.6
5.4	5.8	7.7
5.6	6.3	8.3
7.2	9.3	9.0
7.6	9.9	9.9
9.1	10.6	10.3
9.3	12.6	11.6
10.2	13.3	12.0
11.2	15.8	12.4
11.4	16.1	13.8
12.2	16.4	14.2
13.0	16.9	15.8
13.8	18.1	16.2
13.9	18.1	17.0
15.0	19.4	17.7
15.8	20.7	17.9
18.0	21.2	18.2
18.3	21.8	18.9
19.1	22.8	19.3
19.8	23.2	20.3