Table 1.
Classification of EF-hand Proteins
| Family | Subfamily | Proteins |
|---|---|---|
| CTER (calmodulin, troponin C, essential and regulatory light chain) subfamily | calmodulin, troponin C, essential light chain of myosin, regulatory light chain of myosin | |
| Others: Ca2+/CaM protein kinase, calsenilin, DREAM, calcineurin B like (CBL) sensors | ||
| CRP (calcineurin B, p22, recoverin) subfamily | calcineurin B, p22, recoverin (and other neuronal calcium sensor family) | |
| Others: Ca2+/CaM protein kinase, calsenilin, DREAM, calcineurin B like (CBL) sensors | ||
| S100 subfamily | S100, calbindin D9k, P26olf (dicalcin) | |
| Fused gene family: profilaggrin, trichohyalin, repetin, hornerin, profilaggrin-related protein, cornulin | ||
| Other EF-hand subfamilies showing no strong congruence to one another | PENTA-EF-hand subfamily | Group II (calpain, calcium-dependent proteases, sorcin, grancalcin), Group I (ALG-2, peflin) |
| Proteins with six EF-hands | calbindin D28k, calretinin, Eps15 homology domain, CREC family (Ca2+-binding protein of 45 kDa, reticulocalbin, ER Ca2+-binding protein of 55 kDa, and calumenin), Plasmodium falciparum surface protein, calsymin | |
| Proteins with eight and 12 EF-hands | Lytechinus pictus SPEC-resembling protein, EF12 | |
| Proteins with four EF-hands | Tetrahymena pyriformis calcium binding protein TCBP-25, TCBP-23, CBP, calcyphosine, Strongyrocentrotus purpuratus Ectoderm calcium binding protein SPEC, calflagin, sarcoplasm calcium binding protein, Hra32, EFH5, calcium vector protein, PM129 clone from Arabidopsis thaliana, calcium and integrin binding protein, spasmin, aequorin, Plasmodium falciparum protein kinase (PFCPK), protein phosphatase encoded by rdgC, phospholipase C, LAV1 | |
| Proteins with two-EF-hands | Phl p 7 (polcalcin), alpha-actinin, alpha-spectrin, calmodulin-related gene product encoded by T+, calsensin, groovin, diacylglycerol kinase, glycerol-3-phosphate dehydrogenase, fimbrin, ras guanyl nucleotide-releasing protein (GRP), polycystin-2, ryanodine receptor protein (RYR), CBL, nucleobindin, allograft inflammatory factor-1, BM-40 (osteonectin) | |
| EF-hand proteins in bacteria and viruses | calerythrin, other EF-hand proteins in bacteria, MSV from pox virus |
The list is based on the chapter 11 of a book by Permyakov and Kretsinger (2011) [69].