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. 2015 Mar 14;17(1):61. doi: 10.1186/s13075-015-0580-y

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© Mahmood et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CDR3 length during IL-6R and TNF-α inhibition. (A) Significant increase in the CDR3 length of Ig-V_H gene rearrangements of DN B cells from the peripheral blood of RA patients during IL-6R inhibition. (^*** P <0.0001). (B) During TNF-α inhibition, a comparable CDR3 length of Ig-V_H gene rearrangements of DN B cells were observed at all time points. (C) There is significant increase in the length of the CDR3 in all three isotypes specific to DN B cells during IL-6R inhibition. P values were determined by Wilcoxon test using GraphPad Prism 5. CDR3, the length of the third complementary determining region; DN, double negative; IL-6R, interleukin-6 receptor; RA, rheumatoid arthritis; TNF-α, tumor necrosis factor alpha.