Skip to main content
. Author manuscript; available in PMC: 2015 Apr 30.
Published in final edited form as: Virology. 2005 Jun 5;336(2):184–197. doi: 10.1016/j.virol.2005.03.032

Fig. 8.

Fig. 8

V5-gp41, but not V1/V2, of the R3A Env is uniquely involved in HIV replication and pathogenesis in the thymus model. (A) NL4-3 recombinant viruses expressing the indicated Env were used to infect thymus fragments in the HF-TOC system. Replication was monitored by detection of p24 in the TOC supernatant at the indicated times post-infection. Shown are the combined data from five independent infections. (B) Pathogenesis was assessed by depletion of total CD4+ thymocytes using FACS. Shown are the combined results from five independent experiments. *Indicates significant differences in depletion relative to both NL4-R3B and NL4-R3A at days 11–12 ( P < 0.05).