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. 2015 Mar 30;16:40. doi: 10.1186/s12882-015-0032-6

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© Nozal et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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First kidney biopsy images, and renal function and complement evolution over 7 years. A) Light microscopy showing a glomerulus with endocapillary hipercellularity and karyorrhexis [hematoxylin-eosin (HE)], upper left panel. Light microscopy showing glomerular subendothelial deposits with wire loops lesions (masson trichrome), upper right panel. Immunoflourescence micrograph showing granular IgG deposits in the glomerular capillary walls, in a diffuse and global distribution, bottom left panel. Immunoflourescence micrograph showing subendothelial deposits of C3, bottom right panel. B) Seven year evolution of C3 and C4 levels, serum creatinine and proteinuria. Arrows indicate hospitalizations and renal biopsies due to nephrotic syndrome and renal insufficiency.