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. 2015 Apr 30;5:9783. doi: 10.1038/srep09783

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(a) The suppression of ASS1 expression inhibits cell migration in the MKN45 cell line, and this effect is associated with a decrease in STAT3 protein expression. (b) The overexpression of ASS1 increases cell migration in the AGS cell line, and this effect is associated with an increase in STAT3 expression. (c) ASS1 silencing in the 3IB2 mouse gastric cancer cell line inhibits cell migration and tumor metastasis, and these effects are associated with decreased STAT3 expression. ASS1 silencing, ectopic ASS1 expression and the arginine concentration affect cell migration in gastric cancer cell lines.