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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Birth Defects Res A Clin Mol Teratol. 2015 Mar 16;103(4):276–283. doi: 10.1002/bdra.23362

Figure 3.

Figure 3

Location of DNA copy number deletions and test results for equal transmission rates of copy number components between case and control trios in the MGAM region on chromosome 7q34 (left) and the ADAM3A / ADAM5 region on chromosome 8p11 (right). The genomic locations of the components are indicated by vertical bars on the ideograms (top panels), and overlapped with nearby genes (middle panels). Test results are shown as nominal −log10(p) from Fisher's exact test for the respective CNV components, with the genome-wide significance level indicated by a dashed line (bottom panels). There is clear evidence of over-transmission of a deletion CNP in the MGAM region. The ADAM3A / ADAM5 region also contains a possible region of over-transmission.