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Simulation of pharmacokinetic model for repeated intermittent dosing regimen (50 mg once daily) (A) and continuous dosing regimen (37.5 mg once daily) (B) (n = 1000). The lines represent the median concentration; the areas represent 25th-75th percentile intervals. The dark grey shows concentration-time profile of sunitinib; the light grey shows SU12662. 
, median sunitinib; 
, median SU12662; 
, 25th-75th percentile sunitinib; 
25th-75th percentile SU12662
