Table 1.

Characteristics of patients and studies

	Number of patients	Number of samples	Dose (mg)	Weight (kg) median (range)	Sampling time points post-dose (h)
All	70	1205	25, 37.5, 50	82 (39–157)
Study 1 [18]	50	703	25, 37.5, 50	85 (39–157)	0, 4, 8, 24
Study 2 20	7	112	25, 37.5, 50	96 (53–105)	0, 1, 2, 4, 6, 8, 12, 24
Study 3 21	13	390	37.5, 50	70 (57–98)	0, 0.17, 0.33, 0.67, 1, 2, 3, 4, 5, 6, 7, 8, 10, 12, 24