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Mean plasma concentration–time profiles of apixaban (error bars show one standard deviation) in healthy subjects following a single 10 mg dose of apixaban alone or in the presence of multiple doses of (A) ketoconazole, 
, apixaban 10 mg (n = 19); 
, apixaban + ketoconazole 400 mg once daily (n = 18) and (B) diltiazem, 
, apixaban 10 mg (n = 18); 
, apixaban 10 mg + diltiazem 360 mg once daily (n = 18)
