Table 1. Demographic and clinical Data of the patients.

Pat.	Diagnose	MRI findings	Age at EEG	AED	Type of seizures
1 1	HIE a	Signal abnormality and swelling of basal ganglia and thalami	1 day	PB	No clinical seizures
2 1	HIE b	Global cerebral, basal ganglia and thalamus infarction	13 mo	MDL	No clinical seizures
3 1	Epileptic encephalopathy	brain malformation, simplified gyration, hypoplastic cerebellum	1 mo	none	No clinical seizures
4 1	Neurometabolic disease c	Multiple, bilateral hemorrhages	5 day	none	No clinical Seizures
5 1	HIE, IC hemorrhage	Brain atrophy d	3 days	PB	No clinical Seizures
6 1	Migrating epilepsy	Normal	7 mo	PHT, CLZ, ZNS, Ketogenic diet	Focal motor and Tonic seizures
7 1	Non-ketotic hyperglycinaemia	Mild delay of myelination	2 mo	PB	Tonic seizures
8 1	HIE, ICH	Intracerebral Heamorrhage, oedema e	6 days	PB, PHT	No clinical seizures
9 1	Metabolic	bilateral perisylvian and insular polymicrogyria	6 weeks	PB	Tonic seizures
10 2	Focal epilepsy. later West-Syndrome	Delay of myelination, potentially focal cotical dysplasia	8 mo	OXC, VPA, STP	Focal tonic seizures
11 2	EME DD: Otahara	Delay of myelination, progressive atrophy of white matter	11 mo	PHT, CLB, TPM, CLB	Tonic seizures in series, polytopic myoclonia
12 2	Focal epilepsy. later West-Syndrome	No definitely pathological finding	1 yr	STM, VGB	Tonic-clonic seizures
13 2	Focal epilepsy. later West syndrome	Myelination delay, focal cortical dysplasia of the left frontal lobe	9 mo	PHT, CLB	Epileptic spasms in series

List of abbreviation: AED Antiepileptic drugs; EEG Electroencephalography; PB Phenobarbital; MDL Midazolam; PHT Phenytoin; CLZ Clonazepam; ZNS Zonisamid; OXC—Oxcarbazepin, CLB Clobazam, STP Stiripenton. VGB Vigabatrin, STM Sulthiam. HIE hypoxic ischemic encephalopathy; IC intracranial Hemorrhage;

¹ Patients from the Department of Neurophysiology, Great Ormond Street Hospital for children, London, UK.

² Patients from the Department of Neuropediatrics at the University Hospital of Schleswig-Holstein, campus Kiel and the Northern German Epilepsy Centre for children & adolescents, Schwentinental/Raisdorf, Germany

^a Severe perinatal hypoxic ischemic encephalopathy

^b Severe hypoxic ischemic encephalopathy due to an aspiration with the grape and respiratory and cardiac arrest.

^c DD: thromboembolic disease or genetic / mitochondrial disease.

^d Marked brain atrophy, almost no remaining occipital parenchymal tissue. No underlying structural cause for the previous hemorrhage.

^e Intraventricular haemorrhage, hydrocephalus. Diffuse cerebral hemisphere oedema. Left cerebellar and infra and supratentorial subdural haematoma, A small non-compressive intradural haematoma in the upper thoracic spine, subarachnoid haemorrhage.