Skip to main content
. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Exp Neurol. 2014 Sep 28;263:244–253. doi: 10.1016/j.expneurol.2014.09.016

Figure 6.

Figure 6

ALDH2 activator, Alda-1, exerts a neuroprotective effect against rotenone-induced death of SN TH+ dopaminergic neurons. (A) Immunohistochemical staining demonstrated the loss of TH+ dopaminergic neurons in the SN after rotenone administration. Alda-1 treatment ameliorated rotenone- or MPTP-induced reduction in the number of SN TH+ dopaminergic neurons. (B) Quantification of SN TH+ dopaminergic neurons showed that Alda-1 reduced rotenone- or MPTP-induced loss of SN dopaminergic neurons. Administration of Alda-1 greatly reduced rotenone-induced death of SN TH+ dopaminergic neurons. Alda-1 treatment was also effective to significantly reduce MPTP-induced loss of SN TH+ dopaminergic neurons. Each bar shows the mean ± SD value from 6 animals. ***p<0.001 compared to rotenone- or MPTP-treated mice.