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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Neurobiol Dis. 2015 Mar 11;77:246–256. doi: 10.1016/j.nbd.2015.03.001

Figure 1. Characterization of seizure frequency and duration in chronically epileptic rats.

Figure 1

(A) Summary of seizure data obtained during a 7-day monitoring period that occurred prior to sacrifice. The ≤3 hours group (n=15) demonstrated a significantly higher (p<0.0001, unpaired t-test) seizure frequency (i.e., seizures/day) relative to the ≥24 hours group (n=13) that showed infrequent seizures. (B) Seizure frequency in both groups of epileptic animals shows that the ≤3 hours group had more frequent seizures on daily bases when compared to the number of seizures showed by the ≥24 hours group. (C) Representative EEG traces detected in pilocarpine-treated rats that correspond to spontaneous seizures correlated with either non-convulsive or convulsive behaviors. (D) Electrographic seizures were classified as convulsive (Racine scale ≥ 3) or non-convulsive (Racine scale ≤ 2). The mean daily seizure frequency demonstrates a significant decrease in the rate of non-convulsive seizures in the ≥24 hours group relative to the ≤3 hours group (p<0.0001, ANOVA). (E) A significant increase in seizure duration (p=0.013) was observed in the group with infrequent seizures (≥24 hours group) relative to the group with more frequent/recent seizures (≤3 hours group).