Table 2.
Summary of the most salient changes observed in the different parameters examined in this study. Arrows indicate either a significant increase (↑) or a decrease (↓) and the symbol (•) represents no change in the parameter described.
| GABAAR | Frequent Seizures | Infrequent Seizures | |
|---|---|---|---|
| Cell Surface | Biotin | ||
|
| |||
| α1 | • | ↑ | |
| α4 | ↑ | ↑ | |
| β2/3 | • | • | |
| δ | • | ↑ | |
|
| |||
| Composition | Western Blot | ||
|
| |||
| IP α1 | α4 | ↑ | ↑ |
|
|
|||
| β2/3 | • | • | |
| γ2 | • | • | |
|
| |||
| Function | Phasic | ||
|
| |||
| Zolpidem | Amplitude | ↑ | • |
| Δ Decay Time | ↑ | • | |
| Population Shift | ↑ | • | |
|
| |||
| Function | Tonic | ||
|
| |||
| Δ Base line | ↓ | • | |
|
| |||
| EEG | |||
|
| |||
| Spike Rate | ↑ | ↑ | |
| Mean Power | ↓ | • | |