Table 2.
IC50 values-based neutralization comparison between pairs of HMAb
| HMAb | CBH-5 | CBH-7 | HC-11 | HC-1AM | HC33.4.10 | HC84.24 | HC84.26 | AR3A | AR4A | AR5A |
|---|---|---|---|---|---|---|---|---|---|---|
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| CBH5 | 14 vs 1 | 7 vs 8 | 3 vs 13 | 9 vs 6 | 1 vs 15 | 1 vs 14 | 9 vs 7 | 8 vs 8 | 13 vs 3 | |
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| CBH7 | 0 vs14 | 0 vs 16 | 2 vs 12 | 0 vs 16 | 0 vs 14 | 1 vs 15 | 0 vs 16 | 1 vs 15 | ||
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| HC-11 | 7 vs 9 | 10 vs 5 | 4 vs 12 | 2 vs 13 | 9 vs 6 | 8 vs 8 | 13 vs 2 | |||
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| HC-1AM | 13 vs 3 | 5 vs 11 | 3 vs 13 | 7 vs 9 | 9 vs 7 | 13 vs 3 | ||||
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| HC33.4.10 | 3 vs 13 | 1 vs 14 | 7 vs 9 | 5 vs 11 | 11 vs 4 | |||||
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| HC84.24 | 4 vs 12 | 13 vs 3 | 11 vs 5 | 16 vs 0 | ||||||
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| HC84.26 | 13 vs 3 | 14 vs 2 | 14 vs 1 | |||||||
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| AR3A | 8 vs 8 | 13 vs 2 | ||||||||
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| AR4A | 13 vs 3 | |||||||||
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| AR5A | ||||||||||
The efficacy difference between HMAbs neutralization was analyzed by comparing each HCVcc IC50-values (<100 μg/ml) of one HMAb with IC50-values from the corresponding HCVcc of another HMAb followed by calculation of statistical significance using Fisher’s exact test.
Numbers in the matrix to the left of vs relates to HMAbs in the left column and number to the rigth related to HMAbs in top row Statistical significant p-values <0.05 is displayed in blue and <0.01 in purple. Non-significant values are shown in black.