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. 2015 Apr 1;2(2):ENEURO.0029-14.2015. doi: 10.1523/ENEURO.0029-14.2015

Figure 3.

Figure 3

eCB-mediated iLTD requires endogenous BDNF signaling as well as DGL. A, Group time course showing the lack of effect of seven trains of TBS (7× TBS) on peak eIPSC amplitude in the presence of the tyrosine kinase inhibitor K252a (200 nM, n = 6). B, Group time course showing the lack of iLTD in response to 7× TBS in the presence of the trkB receptor antagonist ANA12 (10 μM, n = 6). Inset, Averaged sample sweeps during baseline (1) and 35 min after TBS (2) from a representative experiment. C, Group time course showing the lack of iLTD in response to 7× TBS in the presence of DGL inhibitor THL (5 μM, n = 6). D, Compiled group data for normalized eIPSC amplitude at 35 min postinduction in the presence of K252a (light pink bar), ANA-12 (light purple bar), or THL (coral bar). The effect of 7× TBS in vehicle (blue bar) was taken from Figure 2C for comparison. *p < 0.05 compared to baseline.