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. 2015 May 1;8(5):487–499. doi: 10.1242/dmm.017046

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Ultrastructure of the bronchial wall of Adamtsl2^−/− mice. (A-F) Ultrastructural analysis of the newborn bronchial wall using TEM. In contrast to WT bronchial epithelium (A,C), the bronchial epithelium in Adamtsl2^−/− (−/−) mice is disorganized (B,D,E) and membrane-bound vesicles engorged with granular, electron dense material fill mutant cells and the lumen (E,F). (G-H) The SMC layer of the bronchial wall did not show consistent differences between WT and Adamtsl2^−/− mice. (I-J) Higher magnification of the ECM around the bronchial SMCs (from n=4 per genotype). B, Bronchi; Col, collagen fibers; EF, elastic fiber; EP, bronchial epithelium; MF, microfibril.