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. 2015 May 1;8(5):487–499. doi: 10.1242/dmm.017046

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 7. — ADAMTSL2 binds to FBN1 and FBN2. (A) Domain structure of human FBN1 and FBN2. The peptides used in the binding assays with ADAMTSL2 are marked with brackets. (B) ADAMTSL2 (left, preparation A and B) and fibrillin peptides (right) were separated on 7.5% polyacrylamide gels under reducing conditions followed by Coomassie staining to demonstrate the purity of protein preparations. (C) Binding of immobilized ADAMTSL2 to soluble N- or C-terminal fragments of FBN1 or FBN2, respectively, was measured by surface plasmon resonance (Biacore) (n=2). The K_D for FBN1-N was similar to that previously published for a slightly different N-terminal fragment (60 nM) (Le Goff et al., 2011).