Fig. 2.

Comparative and phylogenetic analyses of composite islands encoding mecA and fusC. (A) Staphylococcal cassette chromosome (SCC) elements that encode fusC as the only antimicrobial resistance (in teal) were adjacent to a second SCC (SCCmecIV, in grey) in composite islands in ST1 and ST149 (and its single-locus variant ST2942). The direct repeat sequences (DR_scc) that delimit each SCC are shown as vertical red lines topped by a black square. (B) Phylogenetic analysis and comparison with previously identified cassettes SCC₄₇₆ and SCCfusC (in black) identifies two distinct SCCs that were unique to ST1 in purple (SCC₄₇₆) or ST149 in green. The novel cassette in found in ST149 isolates was designated SCC₁₄₉.