Table 3.

Activation differences between rMDD patients (n = 78) and HC (n = 42).

Region	BA	Cluster (mm3)	z	p	x	y	z
rMDD patients (n = 78) vs. HC (n = 42)
PCG	3, 40	1760	−3.87	<0.001**	−38	−32	58
amPFC	10	1571	−3.61	<0.001*	8	48	12
STG	42	1184	−3.52	<0.001*	58	−11	10
PCC	24	1027	−3.44	<0.001+	3	22	32
Adolescent-onset rMDD patients (n = 42) vs. HC (n = 42)
amPFC	10	6976	−4.33	<0.001**	5	46	12
PCC	24	5730	−4.20	<0.001**	5	−17	36
STG	42	1561	−3.70	<0.001*	58	−13	10
STG	43	1100	−3.45	<0.001+	−51	−6	14
STG	3, 40	1016	−3.43	<0.001+	−38	−32	58

Positive/negative z-scores represent increased/decreased deactivation of rMDD patients versus HC (two-back vs. zero-back); x, y, z are coordinates in Talairach space (LPI). Abbreviations: **, highly significant (FWE corrected p < 0.01); *, significant (FWE corrected p < 0.05); ⁺, trend-wise significant (FWE corrected + p < 0.10); BA, Brodmann area; rMDD, remitted Major Depressive Disorder; HC, healthy controls; FWE, family-wise error rate; PCG, postcentral gyrus; amPFC, anterior-medial prefrontal cortex; PCC, posterior cingulate cortex; STG, superior temporal gyrus.