Table 4.

Differences in functional connectivity between adolescent-onset rMDD patients (n = 42) and HC (n = 42).

Region	Seed	BA	Cluster (mm3)	z	p	x	y	z
MedFG	amPFC	10	1687	−3.52	<0.001**	3	59	17
dlPFC	amPFC	9, 8	1446	3.52	<0.001*	−27	33	43
Precuneus	dlPFC	31	4745	−4.22	<0.001**	25	−41	36
SupMidFG	dlPFC	8, 9	2409	−4.44	<0.001**	38	35	36
amPFC	dlPFC	10	2388	3.94	<0.001**	−10	46	1
MidFG	dlPFC	6	2273	−4.23	<0.001**	27	3	41
SupMidFG	dlPFC	10	1257	−3.44	<0.001*	−27	48	17
SupMidFG	dlPFC	6	1246	−3.95	<0.001*	−18	−7	65

Positive/negative z-scores represent increased/decreased functional connectivity. Seeds are in the amPFC (5, 46, 12) and the dlPFC (−25, 26, 38). Significance is indicated by * (FWE corrected **p < 0.01, *p < 0.05); x, y, z are coordinates in Talairach space (LPI). Abbreviations: BA, Brodmann Area; rMDD, remitted Major Depressive Disorder; HC, healthy controls; dlPFC, dorsolateral prefrontal cortex; amPFC, anterior-medial prefrontal cortex; SupMidFG, superior and middle frontal gyrus; MidFG, middle frontal gyrus; MedFG, medial frontal gyrus.