Fig 3. Exacerbation of peripheral neuropathy induced by combined treatment with oxaliplatin and aluminum chloride.

5% dextrose, aluminum chloride (AlCl₃·6H₂O, 7 mg/kg; equivalent 0.78 mg/kg of elemental Al), and oxaliplatin (3 mg/kg) were administered by i.p injection for 24 days including 5 days of rest. (a). Acetone test for cold allodynia was performed before the first infusion and then every 15 days (b). Hypersensitivity to cold stimuli was synergistically increased in mice treated with both oxaliplatin and aluminum chloride. Cont (●: 5% dextrose), Al (x: aluminum chloride, 7 mg/kg), Oxal (□: oxaliplatin, 3 mg/kg), Al & Oxal (★: aluminum chloride 7 mg/kg and oxaliplatin 3 mg/kg). Results are representative of two independent experiments. Values are expressed as the mean ± SEM (n = 10 per group). ^a p < 0.05, ^aaa p < 0.001 compared with the control or oxaliplatin group. BT: behavioral test, BW: body weight