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. 2015 Apr 30;10(4):e0124875. doi: 10.1371/journal.pone.0124875

Fig 4. Accumulation of aluminum (Al) and Platinum (Pt) in DRG tissue after drug treatment.

Fig 4

Total elemental contents including Al and Pt were assayed in DRG tissues by inductively coupled plasma mass spectrometry (ICP-MS) after performing treatments for 30 days according as the schedules shown in Figs 1a (a) and 3a (b). Al accumulated to significantly higher concentrations in the DRG from the Oxal (oxaliplatin 3 mg/kg) group than in the DRG from Cont (5% dextrose) or Gem (gemcitabine 100 mg/kg) groups (n = 6 per group) (a). Effect of combined treatment with oxaliplatin and aluminum chloride on the elemental composition of DRG tissues. The DRGs from the Cont (5% dextrose), Al (aluminum chloride 7 mg/kg), Oxal (oxaliplatin 3 mg/kg), Al & Oxal (aluminum chloride 7 mg/kg; equivalent 0.78 mg/kg of elemental Al, oxaliplatin 3 mg/kg) groups were analyzed by ICP-MS. Al concentrations increased synergistically in tissues of the combined-treatment group compared to the Al or Oxal groups (n = 10 per group) (b). Results are representative of two independent experiments. Values are expressed as the mean ± SEM. *p < 0.05, ***p < 0.001 compared with the Gem group, + p < 0.05, +++ p < 0.001 compared with the Cont group, **p < 0.01 compared with Oxal and Al & Oxal.