Figure 2.

Examples of layered networks. (A) A network with three layers: domain layer (top), protein–protein interaction layer (middle) and function layer (bottom). The protein–protein interaction layer contains ENSP00000000442 and its interacting partners within distance 2. Relationships between layers are shown with cyan lines, and relationships within a layer are shown with red lines. (B) A network with two layers: function layer (top) and protein layer (bottom). The protein layer contains proteins involved in cell cycle regulation (7) and their interacting partners within distance 1. Relations between layers are shown with cyan lines, and relations within layers are shown with red lines. protein–protein interactions and functional catalogs were obtained from MIPS. Ellipses, rounded rectangles and rectangles represent functions, proteins common to genetic and physical interactions and rest proteins, respectively.