Table 2. Effect of DAPA on body weight, fluid balance and electrolytes in normal SD rats.

Time point	Baseline		Day 18		Day 35
Treatment group	CON	DAPA	CON	DAPA	CON	DAPA
Number of animals	9	9	9	9	9	8
Age, week	5	5	7.5	7.5	10	10
Body weight, g	144 ± 2	149 ± 7	285 ± 5	297 ± 7	349 ± 5	354 ± 6
Water intake, ml/d	32 ± 1	32 ± 3	41 ± 2	54 ± 2***	49 ± 3	62 ± 7*
Diuresis, ml/d	11 ± 1	12 ± 1	17 ± 2	24 ± 3*	32 ± 2	36 ± 4
PNa +, mmol/l	138.9 ± 0.4	142.3 ± 3.4	138.4 ± 0.4	133.5 ± 1.6*	141.9 ± 0.5	140.4 ± 0.6
PCl -, mmol/l	100.9 ± 0.3	100.6 ± 1.0	100.3 ± 0.3	94.0 ± 3.0	100.9 ± 0.3	95.9 ± 2.3
Pglucose, mmol/l	10.5 ± 0.6	10.3 ± 0.2	9.9 ± 0.2	9.7 ± 0.3	13.4 ± 0.2	13.0 ± 0.5
UNa +, mmol/d	1.3 ± 0.1	1.2 ± 0.1	1.1 ± 0.1	1.4 ± 0.1	1.1 ± 0.3	1.6 ± 2.0
UCl -, mmol/d	2.1 ± 0.1	1.8 ± 0.2	1.8 ± 0.1	2.1 ± 0.1	2.3 ± 0.1	2.4 ± 0.5
Uglucose, mmol/d	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	10.6 ± 0.6***	0.0 ± 0.0	13.5 ± 2.0***

Data are expressed as means ± SE. CON, vehicle control; DAPA, dapagliflozin.

*P<0.05

**P<0.01

***P<0.001, when comparing DAPA and CON at each time point. P, plasma; U, urine.