Figure 5.

Activity Changes of Arkypallidal and Prototypic GPe Neurons Are Different during Spontaneous Movement

(A–D) Example single-unit activity (left), electromyograms (EMG, lower traces), and individual peri-event time histograms (PETH) and raster plots for three different prototypic (Nkx2-1+/PV+) GPe neurons (A)–(C) and an arkypallidal (FoxP2+) neuron (D) during brief spontaneous movements (denoted by black bars). Prototypic neurons (n = 43) could be subdivided into three groups based on the polarity of their firing rate changes during movement (mean, normalized PETH ± SEM shown for each group, right).

(A) During movement, 22 of 43 prototypic neurons significantly decreased their firing rate.

(B) During movement, three prototypic neurons showed no significant change.

(C) During movement, 18 prototypic neurons significantly increased their rate.

(D) In contrast, arkypallidal neurons (n = 10) uniformly increased their firing rates during movement (nine showed significant increases).

Mean movement duration is denoted by gray shading. In raster plots, the end of individual movement epochs is indicated by red lines.