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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Nat Chem Biol. 2014 Nov;10(11):884–891. doi: 10.1038/nchembio.1670

Figure 5. Competition between ubiquitin binding and aggregation for the Josephin domain of Atx3.

Figure 5

A surface representation of Josephin (PDB code 2JRI) is shown in white with exposed hydrophobic surfaces in green. When in the presence of the natural partner ubiquitin (Ub; the two binding ubiquitins are shown as blue traces), the Josephin binding sites are saturated by the interaction and protected from aggregation. When interaction is impaired, for instance by polyQ expansion, which alters the affinity for the interactor, the two sites promote aggregation, as shown in the right panel. Adapted from ref. 15 with permission from Elsevier.