Figure 1.

Peptide AB103 blocks induction of tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) by lipopolysaccharide (LPS) in human peripheral blood mononuclear cells (PBMCs). Human PBMCs were stimulated with 0.1 µg/mL LPS alone (○) or in the presence of 0.1 (▴), 1 (♦), or 10 µg/mL (▪) of AB103 added 10 minutes prior to stimulation with LPS. At the indicated times, secreted levels of TNF-α (A) and, in a separate experiment, IL-6 (B) were assayed. Data are means ± SD (n = 3). See also Supplementary Figure 1.