Table 1.

Cytokine and Chemokine Levels in Peritoneal Fluid Samples Obtained From Mice 12 or 24 Hours After Sham Surgery, Cecal Ligation/Puncture (CLP) Plus Vehicle Treatment, or CLP Plus AB103 Treatment

Cytokine/Chemokine, Time Point	Sham	CLP + Vehicle	CLP + AB103
TNF-α
12 h	9 ± 3	276 ± 43	235 ± 33
24 h	1 ± 1	174 ± 33	51 ± 13a
RANTES
12 h	8 ± 0	163 ± 22	121 ± 22
24 h	4 ± 2	165 ± 41	74 ± 15b
KC
12 h	0 ± 0	154 ± 10	120 ± 5a
24 h	1 ± 0	30 ± 4	25 ± 1
IL-17A
12 h	0 ± 0	144 ± 43	111 ± 58
24 h	1 ± 1	214 ± 63	118 ± 38
IL-3
12 h	7 ± 3	99 ± 23	37 ± 12a
24 h	7 ± 3	82 ± 74	14 ± 15
MCP-1
12 h	520 ± 117	6317 ± 1005	6684 ± 987
24 h	91 ± 20	2344 ± 606	1265 ± 544
IL-10
12 h	15 ± 5	440 ± 119	338 ± 119
24 h	8 ± 3	165 ± 63	142 ± 71
IL-6
12 h	295 ± 59	8046 ± 919	7946 ± 1202
24 h	30 ± 12	4294 ± 759	4040 ± 853

Data are mean pg/mL (±standard error of the mean), with 5–8 mice/group.

Abbreviations: IL-3, interleukin 3; IL-6, interleukin 6; IL-10, interleukin 10; IL-17A, interleukin 17A; KC, keratinocyte-derived chemokine; MCP-1, monocyte chemoattractant protein 1; RANTES, regulated upon activation, normal T cell expressed and secreted; TNF-α, tumor necrosis factor α.

^a P ≤ .05, vs vehicle-treated CLP group (TNF-α: P = .008; KC: P = .023; IL-3: P = .050).

^b P = .056. All other P values > .23).