Table1.
Associations of 13 tag SNPs in PFKFB2 with maximum BMI in adulthood and maximum BMI z-score in childhood in individuals from the GRIC including full-heritage Pima Indians and mixed-heritage AI; and comparison with data from GIANT*
| SNP | Location | R/N | Full-heritage Pima Adult BMI (n = 3412) BMI z-score (n = 2296) |
Mixed-heritage AI Adult BMI (n = 3427) BMI z-score (n = 3054) |
Entire GRIC (combined) Adult BMI (n = 6839) BMI z-score (n = 5350) |
GIANT*(n = 123795) |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RAF | Beta | P | RAF | beta | P | Beta | P | R/N | RAF | P | |||
| rs78357410 | 5′flanking | T/C | 0.05 | 1.008 0.004 |
0.54 0.96 |
||||||||
| rs79168343 | 5′flanking | C/T | 0.94 | 1.024 0.052 |
0.03 0.43 |
0.95 | 1.011 0.019 |
0.42 0.76 |
1.019 0.034 |
0.03 0.46 |
|||
| rs12032074 | 5′flanking | A/G | 0.85 | 1.006 −0.057 |
0.47 0.19 |
||||||||
| rs2243816 | intron | T/C | 0.22 | 1.011 0.023 |
0.08 0.53 |
0.20 |
1.012 0.037 |
0.09 0.31 |
1.012 0.033 |
0.01 0.21 |
T/C | 0.14 | 0.25 |
| rs11120137 | intron | T/C | 0.11 | 1.025 0.133 |
0.008 0.01 |
0.20 | 1.020 0.091 |
0.01 0.02 |
1.022 0.108 |
2.0 × 10−4 7.6 × 10−4 |
T/C | 0.55 | 0.65 |
| rs77757597 | 3′UTR | G/T | 0.64 | 1.011 0.070 |
0.07 0.03 |
0.72 | 1.001 −0.009 |
0.84 0.78 |
1.006 0.030 |
0.16 0.18 |
|||
| chr1:207250175 | 3′UTR | T/C | 0.04 | 1.010 −0.054 |
0.47 0.40 |
||||||||
| rs1060286 | 3′UTR | G/A | 0.01 | 1.032 0.413 |
0.36 0.03 |
0.08 | 1.007 0.025 |
0.55 0.69 |
1.010 0.066 |
0.41 0.27 |
A/G | 0.57 | 0.60 |
| rs17258746 | 3′UTR | A/T | 0.10 | 1.029 0.103 |
0.004 0.06 |
0.11 | 1.016 0.057 |
0.09 0.24 |
1.023 0.079 |
7.3 × 10−4 0.03 |
A/T | 0.14 | 0.24 |
| rs3748672 | 3′UTR | A/G | 0.01 | 1.046 0.329 |
0.06 0.04 |
0.01 | 1.019 0.110 |
0.07 0.04 |
1.022 0.137 |
0.03 0.007 |
G/A | 0.59 | 0.35 |
| rs6673422 | 3′UTR | G/A | 0.12 | 1.012 0.052 |
0.20 0.31 |
0.12 | 1.012 0.047 |
0.18 0.32 |
1.013 0.051 |
0.04 0.15 |
G/A | 0.13 | 0.21 |
| chr1:207260089 | 3′flanking | T/C | 0.91 | 1.012 0.049 |
0.26 0.37 |
||||||||
| rs56009508 | 3′flanking | A/C | 0.84 | 1.005 0.020 |
0.53 0.61 |
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Adult BMI is the maximum BMI (kg/m2) recorded at age ≥15 years (top row). Childhood BMI z-score is the maximum sex- and age-specific z-score identified between the ages of 5 and 20 years. For association analyses, BMI is loge−transformed, and beta is exponentiated to obtain the effect estimate for each risk allele, expressed as a multiplier. The risk allele (given first) is defined as the allele with a higher BMI. R: risk allele; N: non-risk allele. RAF: risk allele frequency. Beta and p values are adjusted for age, sex, birth-year and heritage. *GIANT meta-analysis (21). Bold values: P < 0.05.