(A) Risk-adjusted Cox proportional-hazards models for major adverse cardiac event by SIS 0, 1–5, and >5 among never, past, and current smokers (n = 9456). (B) Risk-adjusted Cox proportional-hazards models for major adverse cardiac event by normal, non-obstructive, and obstructive CAD among never, past, and current smokers (n = 9456). Adjusted for age, sex, symptoms, dyslipidemia, hypertension, diabetes, family history, and all chest symptoms. MACE, major adverse cardiac events; SIS, segment involvement score; CAD, coronary artery disease. *P < 0.001 and **P < 0.05 for the comparison with never smokers with normal coronary CT angiography.