Anthropometric	Age >80 years old (general caution advised for age >75) Female Low body mass index Asian descent
Concurrent conditions	Acute infection Hypothyroidism (untreated or undertreated) Impaired renal (chronic kidney disease classification 3, 4, and 5) or hepatic function Biliary tree obstruction Organ transplant recipients Severe trauma Human immunodeficiency virus Diabetes mellitus Vitamin D deficiency
Surgery	Surgery with high metabolic demands. The American Heart Association recommends temporary cessation of statins prior to major surgery120
Related history	History of creatine kinase elevation, especially >10× the upper limit of the normal range History of pre-existing/unexplained muscle/joint/tendon pain Inflammatory or inherited metabolic, neuromuscular/muscle defects (e.g. McArdle disease, carnitine palmitoyl transferase II deficiency, myoadenylate deaminase deficiency, and malignant hyperthermia) Previous statin-induced myotoxicity History of myopathy while receiving another lipid-lowering therapy
Genetics	Genetic factors such as polymorphisms in genes encoding cytochrome P450 isoenzymes or drug transporters
Other risk factors	High level of physical activity Dietary effects (excessive grapefruit or cranberry juice) Excess alcohol Drug abuse (cocaine, amphetamines, heroin)