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. Author manuscript; available in PMC: 2016 Jan 27.
Published in final edited form as: Sci Signal. 2015 Jan 27;8(361):ra9. doi: 10.1126/scisignal.2005607

Fig. 2. Fadd null lung tumors are less proliferative.

Fig. 2

(A) Representative histology images of lungs removed from mice 18 weeks after AdCre administration. Tissues were stained with hematoxylin and eosin (HE) or antibodies against cyclin D1, Ki-67, and FADD. Scale bars: 10x, 500 μm; 40x, 200 μm; 100x, 50 μm. (B) Average tumor area quantified from H&E-stained lung tissue sections from KLuc (n=6) and KFLuc (n=10) mice. *P=0.04, unpaired Student’s t-test. (C) Average percentage of positive Ki-67 stained cells in lung tissue sections from KLuc and KFLuc mice, 4 fields per 10 mice each. **P=2×10−5, unpaired Student’s t-test. (D) Representative Western blot for endogenous FADD, GFP (Fadd transgene), phosphorylated and total ERK1/2, phosphorylated RB, cyclin D1, cyclin B1 and β-Actin in lung tissue from the indicated mice. Blots are representative of 3 independent experiments.