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. Author manuscript; available in PMC: 2016 Jan 27.
Published in final edited form as: Sci Signal. 2015 Jan 27;8(361):ra9. doi: 10.1126/scisignal.2005607

Fig. 6. Model for the role of FADD in KRAS-mediated cell proliferation.

Fig. 6

We propose that FADD and CK1α are necessary in mediating mitogenic KRAS signaling in cancer cells. Inhibiting KRAS, MEK or CK1α, or deleting Csnk1a1 or Fadd decreased the abundance of phosphorylated FADD and decreased cell proliferation. We propose cells lacking FADD and CK1α fail to progress through G2/M because the interaction of FADD with key G2/M transition proteins like AURKA, PLK1 or BUB1 is lost.